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HER3 is a member of the epidermal growth factor receptor (EGFR) family, which comprises four closely related tyrosine kinase receptors: HER1 (EGFR), HER2, HER3. Expert commentary, webcast, and downloadable slides on targeting HER2, HER3, and TROP2 in multiple tumor types, from Clinical Care Options (CCO). The disclosure provides monoclonal bispecific antibodies targeting HER2 and HER3. The disclosure also provides monospecific tetravalent HER3 antigen binding.

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[ AACR Poster] Detection of EGFR, HER2, HER3 and HER4 Hetero- and Homodimerization Using EFC-based Cellular Assays Ligand-induced receptor dimerization is. The disclosure provides monoclonal bispecific antibodies targeting HER2 and HER3. The disclosure also provides monospecific tetravalent HER3 antigen binding. HER3 is a member of the epidermal growth factor receptor (EGFR) family, which comprises four closely related tyrosine kinase receptors: HER1 (EGFR), HER2, HER3.

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Zenocutuzumab, a HER2-HER3 Bispecific Antibody, Successfully Targets NRG1 Fusions in Advanced Solid Tumors. June 5, Dr. Alison M. Schram. Key Points. (A) The sequence of HER3 and HER2 are highly conserved in the kinase domain but different in their C-terminal tails. The red box indicates junction regions. HER2 is overexpressed in % of breast cancer patients and most of them benefit from anti-HER2 targeted therapy. · HER2 dimerizes with HER3 to activate PI3K /.